Chemical Safety’s Radioisotope Tracking Software System is designed to help manage the flow of radioisotopes in a multi-user and multi-facility environment. Good safety practices as well as strict federal regulations require that radioisotope use be managed from the facility license down to an isotope’s smallest denomination. By dynamically decaying isotopes in real-time, the Radiation Safety Officer has a real-time view of individual isotope activity at each facility, location, Radioactive Use Authorizations (RUAs) and individual experiments. The system automatically alerts the RSO and Environmental Health and Safety staff via email when an event occurs that has or may cause an issue of compliance or safety. The RTS is easy and intuitive to use and operate through smart menus and actions, it reduces the time required to keep information up-to-date, simplifies the movement, monitoring, and disposal and ensures compliance with facility and isotope license limits.